After completing this chapter, participants will be able to:  

• Understand the importance of genetic testing in clinical electrophysiology and practical cardiology. 
• Learn the basis of interpretation of genetic testing and its potential results with regard to the validity of reported genes and potential gene variants. 
• Learn what is a genetic variant of uncertain clinical significance (VUS, ACMG class 3 variant) and what are secondary findings in actionable cardiovascular genes, which are an upcoming issue in clinical practice. 
• Learn which experimental methods are used to address the functional effects of identified genetic variants and to ascertain a causal relationship between gen variant and disease phenotype.  
• Learn clinical characteristics and genetic basis of the most common primary electrical diseases and inherited cardiomyopathies.  
• Learn when genetic testing is indicated and which genetic test has to be applied in a specific patient according to the phenotype,  
• Recognize the importance of patient counseling and multidisciplinary teams in cardiogenetics.